HSDF supported the development of national health research agendas in The Gambia and Ethiopia, helping stakeholders identify priority research areas and strengthen the role of evidence in shaping health policy, planning, and investment decisions.

HSDF partnered with the World Health Organization (WHO) to examine strategic purchasing approaches in Nigeria, generating evidence to support more efficient use of health resources, stronger health financing systems, and improved access to quality healthcare services.

HSDF supported the midterm review of the Nigeria State Health Investment Project (NSHIP), generating evidence and strategic recommendations to assess progress, identify implementation challenges, and strengthen programme performance during the remainder of the project lifecycle.

HSDF partnered with USAID and Results for Development (R4D) to support monitoring, evaluation, and learning activities for the Health Systems Strengthening Accelerator (HSSA), helping generate evidence, capture lessons, and strengthen learning across health systems strengthening initiatives.

HSDF supported the Global Financing Facility (GFF) Strategy Refresh process in Nigeria, helping generate insights and strategic recommendations to strengthen investments in reproductive, maternal, newborn, child, and adolescent health and nutrition.

HSDF partnered with Harvard University to generate evidence on the burden of malaria in Nigeria, supporting a deeper understanding of disease patterns and informing strategies for malaria prevention, control, and health system planning.

HSDF partnered with Duke University and the Bill & Melinda Gates Foundation to examine the factors shaping global health transitions, generating evidence on how countries can navigate changes in disease burden, demographics, development, and donor financing while sustaining health gains.

HSDF partnered with Duke University and the Bill & Melinda Gates Foundation to examine how health programmes and system reforms can be sustainably transitioned through locally driven approaches, generating evidence to support stronger country ownership and long-term health system resilience.

HSDF supported the implementation of the Additional Financing Nigeria State Health Investment Project (AFNSHIP), helping strengthen primary healthcare systems and improve maternal, newborn, and child health service delivery through performance-focused health sector interventions.

HSDF partnered with USAID and Results for Development (R4D) to facilitate cross-country learning on strengthening safe blood systems, enabling health leaders and institutions in Liberia, Malawi, and Rwanda to share experiences, identify best practices, and advance sustainable approaches to blood service delivery.